Multivalent Fusion Protein Vaccine for Lymphatiac filariasis
Identifieur interne : 004096 ( Main/Exploration ); précédent : 004095; suivant : 004097Multivalent Fusion Protein Vaccine for Lymphatiac filariasis
Auteurs : Gajalakshmi Dakshinamoorthy [États-Unis] ; Abhilash Kumble Samykutty [États-Unis] ; Gnanasekar Munirathinam [États-Unis] ; Maryada Venkatarami Reddy [Inde] ; Ramaswamy Kalyanasundaram [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (immunologie), Brugia malayi, Filariose lymphatique (), Humains, Immunité cellulaire, Lymphocytes auxiliaires Th1 (immunologie), Lymphocytes auxiliaires Th2 (immunologie), Production d'anticorps, Protéines de fusion recombinantes (immunologie), Protéines du choc thermique (immunologie), Protéines recombinantes (immunologie), Souris, Souris de lignée BALB C, Tétraspanines (immunologie), Vaccins (immunologie), Vaccins à ADN (immunologie).
- MESH :
- immunologie : Antigènes d'helminthe, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2, Protéines de fusion recombinantes, Protéines du choc thermique, Protéines recombinantes, Tétraspanines, Vaccins, Vaccins à ADN.
- sang : Anticorps antihelminthe.
- Animaux, Brugia malayi, Filariose lymphatique, Humains, Immunité cellulaire, Production d'anticorps, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (blood), Antibody Formation, Antigens, Helminth (immunology), Brugia malayi, Elephantiasis, Filarial (prevention & control), Heat-Shock Proteins (immunology), Humans, Immunity, Cellular, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins (immunology), Recombinant Proteins (immunology), Tetraspanins (immunology), Th1 Cells (immunology), Th2 Cells (immunology), Vaccines (immunology), Vaccines, DNA (immunology).
- MESH :
- chemical , blood : Antibodies, Helminth.
- chemical , immunology : Antigens, Helminth, Heat-Shock Proteins, Recombinant Fusion Proteins, Recombinant Proteins, Tetraspanins, Vaccines, Vaccines, DNA.
- immunology : Th1 Cells, Th2 Cells.
- prevention & control : Elephantiasis, Filarial.
- Animals, Antibody Formation, Brugia malayi, Humans, Immunity, Cellular, Mice, Mice, Inbred BALB C.
Abstract
Lymphatic filariasis affects approximately 3% of the whole world population. Mass drug administration is currently the major control strategy to eradicate this infection from endemic regions by year 2020. Combination drug treatments are highly efficient in controlling the infection. However, there are no effective vaccines available for human or animal lymphatic filariasis despite the identification of several subunit vaccines. Lymphatic filariasis parasites are multicellular organisms and potentially use multiple mechanisms to survive in the host. Therefore, there is a need to combine two or more vaccine candidate antigens to achieve the desired effect. In this study we combined three well characterized vaccine antigens of
Url:
DOI: 10.1016/j.vaccine.2012.09.055
PubMed: 23036503
PubMed Central: 3554871
Affiliations:
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Le document en format XML
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id="A1">Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107</wicri:regionArea><wicri:noRegion>IL-61107</wicri:noRegion></affiliation></author><author><name sortKey="Samykutty, Abhilash Kumble" sort="Samykutty, Abhilash Kumble" uniqKey="Samykutty A" first="Abhilash Kumble" last="Samykutty">Abhilash Kumble Samykutty</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107</wicri:regionArea><wicri:noRegion>IL-61107</wicri:noRegion></affiliation></author><author><name sortKey="Munirathinam, Gnanasekar" sort="Munirathinam, Gnanasekar" uniqKey="Munirathinam G" first="Gnanasekar" last="Munirathinam">Gnanasekar Munirathinam</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107</wicri:regionArea><wicri:noRegion>IL-61107</wicri:noRegion></affiliation></author><author><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram-442102, Maharashtra, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram-442102, Maharashtra</wicri:regionArea><wicri:noRegion>Maharashtra</wicri:noRegion></affiliation></author><author><name sortKey="Kalyanasundaram, Ramaswamy" sort="Kalyanasundaram, Ramaswamy" uniqKey="Kalyanasundaram R" first="Ramaswamy" last="Kalyanasundaram">Ramaswamy Kalyanasundaram</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Sciences, U of I College of medicine at Rockford, IL-61107</wicri:regionArea><wicri:noRegion>IL-61107</wicri:noRegion></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (blood)</term><term>Antibody Formation</term><term>Antigens, Helminth (immunology)</term><term>Brugia malayi</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Heat-Shock Proteins (immunology)</term><term>Humans</term><term>Immunity, Cellular</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Recombinant Fusion Proteins (immunology)</term><term>Recombinant Proteins (immunology)</term><term>Tetraspanins (immunology)</term><term>Th1 Cells (immunology)</term><term>Th2 Cells (immunology)</term><term>Vaccines (immunology)</term><term>Vaccines, DNA (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (immunologie)</term><term>Brugia malayi</term><term>Filariose lymphatique ()</term><term>Humains</term><term>Immunité cellulaire</term><term>Lymphocytes auxiliaires Th1 (immunologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Production d'anticorps</term><term>Protéines de fusion recombinantes (immunologie)</term><term>Protéines du choc thermique (immunologie)</term><term>Protéines recombinantes (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Tétraspanines (immunologie)</term><term>Vaccins (immunologie)</term><term>Vaccins à ADN (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Helminth</term><term>Heat-Shock Proteins</term><term>Recombinant Fusion Proteins</term><term>Recombinant Proteins</term><term>Tetraspanins</term><term>Vaccines</term><term>Vaccines, DNA</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes d'helminthe</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term><term>Protéines de fusion recombinantes</term><term>Protéines du choc thermique</term><term>Protéines recombinantes</term><term>Tétraspanines</term><term>Vaccins</term><term>Vaccins à ADN</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Brugia malayi</term><term>Humans</term><term>Immunity, Cellular</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Brugia malayi</term><term>Filariose lymphatique</term><term>Humains</term><term>Immunité cellulaire</term><term>Production d'anticorps</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Lymphatic filariasis affects approximately 3% of the whole world population. Mass drug administration is currently the major control strategy to eradicate this infection from endemic regions by year 2020. Combination drug treatments are highly efficient in controlling the infection. However, there are no effective vaccines available for human or animal lymphatic filariasis despite the identification of several subunit vaccines. Lymphatic filariasis parasites are multicellular organisms and potentially use multiple mechanisms to survive in the host. Therefore, there is a need to combine two or more vaccine candidate antigens to achieve the desired effect. In this study we combined three well characterized vaccine antigens of <italic>Brugia malayi</italic>, heat shock protein12.6 (HSP12.6), abundant larval transcript-2 (ALT-2) and tetraspanin large extra cellular loop (TSP-LEL) as a multivalent fusion vaccine. Putative immune individuals carry circulating antibodies against all three antigens. Depletion of these antigen specific antibodies from the sera samples removed the ability of the sera to participate in the killing of <italic>B. malayi</italic> L3 in an antibody dependent cellular cytotoxicity (ADCC) mechanism. Vaccination trials in mice with a bivalent [HSP12.6+ALT-2 (HA), HSP12.6+TSP-LEL (HT) or TSP-LEL+ALT-2 (TA)] or trivalent [HSP12.6+ALT-2+TSP-LEL (HAT)] vaccines using DNA, protein or heterologous prime boost regimen showed that trivalent HAT vaccine either as protein alone or as heterologous prime boost vaccine could confer significant protection (95%) against <italic>B. malayi</italic> L3 challenge. Immune correlates of protection suggest a Th1/Th2 bias. These finding suggests that the trivalent HAT fusion protein is a promising prophylactic vaccine against lymphatic filariasis infection in human.</p></div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Dakshinamoorthy, Gajalakshmi" sort="Dakshinamoorthy, Gajalakshmi" uniqKey="Dakshinamoorthy G" first="Gajalakshmi" last="Dakshinamoorthy">Gajalakshmi Dakshinamoorthy</name></noRegion><name sortKey="Kalyanasundaram, Ramaswamy" sort="Kalyanasundaram, Ramaswamy" uniqKey="Kalyanasundaram R" first="Ramaswamy" last="Kalyanasundaram">Ramaswamy Kalyanasundaram</name><name sortKey="Munirathinam, Gnanasekar" sort="Munirathinam, Gnanasekar" uniqKey="Munirathinam G" first="Gnanasekar" last="Munirathinam">Gnanasekar Munirathinam</name><name sortKey="Samykutty, Abhilash Kumble" sort="Samykutty, Abhilash Kumble" uniqKey="Samykutty A" first="Abhilash Kumble" last="Samykutty">Abhilash Kumble Samykutty</name></country><country name="Inde"><noRegion><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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